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Generic drug for trazodone, divalproex sodium. The most important features of study were that the subjects had tried to self-medicate with benzodiazepines before, but they failed, and that this was accompanied by positive psychotic features that persisted to the time of discharge from hospital after they were discharged. The patients asked to record any other symptoms of psychosis and drug use during the interview, but we were unable to evaluate this in patients with severe comorbid personality pathology. Patients were classified into two groups: 1. patients who self-medicated their benzodiazepine intake with the prescribed benzodiazepines and had positive psychotic symptoms after the discharge from hospital, or 2. patients who self-medicated and did not have positive psychotic symptoms at the time of discharge. Our primary analysis was based on the self-medication group, and our secondary analytical models were based on the patients in other two groups. We used the following covariates: age, sex, use of benzodiazepines (excluding other benzodiazepines), personality disorder—yes, disorder—no, and the severity of comorbidity (symptom scores at baseline, discharge, as well after 2 weeks). We estimated the association between self-medication and severity of comorbidity using an ordinal logistic regression with age, sex, use of benzodiazepines, personality disorder—yes, disorder—no, and symptom severity at the time of discharge from hospital as the dependent variable and combination of comorbidly reported personality disorder—yes, comorbid disorder—no, alcohol misuse-yes, misuse-no, and substance use at discharge as the independent variables. We treated covariates used in this analysis as fixed effects to avoid repeated measurement error. We also performed a secondary analysis using the covariates reported in medical record at 2 weeks or discharge as a predictor. Results In total, 47 patients with schizophrenia and 20 healthy volunteers participated. As expected, most of the patients (59%) was taking at least one medication, most commonly antidepressants (78%), antipsychotics (54%), and psychostimulants together (26%), sedatives (16%). The most common benzodiazepine was diazepam, which accounted for 37% of the total benzodiazepines. majority patients (76%) reported a history of use benzodiazepines before hospital admission, only 30% reported use after 2 weeks.
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